There is need to transform education in Africa even among the orphanage and vulnerable children (OVC) in order to become more competitive and competent in a globalising society through e-learning. Information and communication technologies (ICTs) can be used to enhance learning activities as the instruments of change and the tools of liberation for OVC. Open and Distance Learning (ODL) coupled with application of appropriate ICTs can play a central role in the delivery of education to all levels and provide OVC a chance for a bright future. This paper therefore discusses the concepts of ICTs and ODL and the utilization of ICTs in Open and distance Learning. Finally, it discusses the enhancement of learning for OVC through ICTs in Open and Distance Learning. // Paper ID: 483