In Nigeria, as elsewhere in the world, Open and Distance Learning (ODL) is used as a major vehicle to break the three vectors - access, quality and cost – that has constrained education time immemorial in order to improve women’s wellbeing, reduce their vulnerability and act as a starting point in their empowerment. Using findings from two single-mode ODL institutions in Nigeria, - National Open University of Nigeria (NOUN) and National Teachers Institute (NTI) - this study explores the issues of poverty and women’s empowerment. First, it considers poverty from gender and economic sustainability perspectives, second, it evaluates the impacts of ODL on women empowerment and poverty alleviation, and third, it highlights the role of ODL in enhancing accessible education for women.