This guide to quality assurance of Open, Distance and Flexible Learning (ODFL) provision is intended to support Ministry of Education officials and teachers in the Pacific to roll out high quality distance education in their own contexts. Whilst expansion of ODFL has significantly increased participation in education, upholding the quality of provision cannot be overemphasised. The guide contains six units: (1) Understanding quality and quality assurance in ODFL; (2) Key components of quality in ODFL; (3) Implementing quality in ODFL; (4) Enhancing quality through policy; (5) ICT infrastructure and quality; and (6) optional readings. This guide was developed as part of the Partnership for Open, Distance and Flexible Learning in the Pacific Project, supported by Ministry of Foreign Affairs and Trade, New Zealand.